Practitioner Only Product

 

Folinic Acid

Bioactivated B9

 

Serving Type: Capsule

 

Available In Sizes: 120 capsules

 

Folinic acid is an alternative form of folic acid that bypasses some of the steps in the conversion of folic acid to the active form, 5-methyltetrahydrofolate (5-MTHF). Folinic acid supports healthy methylation pathways, homocysteine metabolism, DNA replication and foetal development.

 

 

Feutures

 

Supports healthy methylation pathways in the body.

Supports healthy homocysteine metabolism.

Involved in the synthesis of S-adenosylmethionine (SAMe).

Helps form red blood cells.

Supports a healthy brain and nervous system function.

Helps support cognitive health, with healthy neural development, growth and repair.

Involved in growth and cellular replication, and contributes to normal growth of the foetus.

Vegetarian friendly.

 

 

Ingredients

 

Each capsule contains:

Calcium folinate : 694mcg

equiv. folinic acid (activated vitamin B9) : 500mcg

 

 

Dose

 

Adults: Take 1 capsule once a day, or as professionally prescribed.

 

 

Warnings

 

• KEEP OUT OF REACH OF CHILDREN.
• Always read the label. Follow the directions for use.
• If symptoms persist, talk to your health professional.
• Supplements may only be of assistance if dietary intake is inadequate.
• Advise your doctor of any medicine you take during pregnancy, particularly in your first trimester.
• If you have any pre-existing conditions, are on any medications, always talk to your health professional before use.
• Some products should be ceased at least two weeks before any elective surgery, please confirm with your health professional.
• Do not exceed the stated dose except on medical advice.
• If you have had a baby with neural tube defect/spina bifida – seek specific medical advice.

 

 

Evidence

 

[1] Refsum H, Ueland PM, Nygard O, et al. Homocysteine and cardiovascular disease. Ann Rev Medicine 1998;49:31-62.

 

[2] Seshadri S, Beiser A, Selhub J, et al. Plasma homocysteine as a risk factor for dementia and Alzheimer’s disease. N Engl J Med 2002;346(7):476-483.

 

[3] Moschiano F, D’Amico D, Usai S, et al. Homocysteine plasma levels in patients with migraine with aura. Neurol Sci 2008;29 Suppl 1:S173-S175.

 

[4] Rochtchina E, Wang JJ, Flood VM, et al. Elevated serum homocysteine, low serum vitamin B12, folate and age related macular degeneration: the Blue Mountains eye study. Am J Ophthalmol 2007;143(2):344-346.

 

[5] van Wijingaarden JP, Doets EL, Szczecinska A, et al. Vitamin B12, folate, homocysteine, and bone health in adults and elderly people: a systematic review and meta-analysis. J Nutr Metab 2013;2013:486186.

 

[6] Gallucci M, Zanardo A, Bendini M, et al. Serum folate, homocysteine, brain atrophy, and auto-CM system: the Treviso Dementia (TREDEM) study. J Alzheimers Dis 2013:PMID 24028866 [Epub ahead of print].

 

[7] Tucker K, Qiao N, Scott T, et al. High homocysteine and low B vitamins predict cognitive decline in aging men: the Veterans Affairs normative aging study. Am J Clin Nutr 2005;82:627-635.

 

[8] Herrmann W, Obeid R. Homocysteine: a biomarker in neurodegenerative diseases. Clin Chem Lab Med 2011;49(3):435-441.

 

[9] Durga J, van Boxtel MPJ, Schouten EG, et al. Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial. Lancet 2007;369: 208-216.

 

[10] Higdon J. An evidenced-based approach to vitamins and minerals. New York: Thieme, 2003.

 

[11] Folic acid/folinic acid. Natural Medicines Comprehensive Database. Viewed 22 Nov 2013, www.naturaldatabase.com

 

[12] Braun L, Cohen M. Herbs and natural supplements: an evidence-based guide, 3rd ed. Sydney: Churchill Livingstone Elsevier, 2010.